Police were called to the scene, near the airport underpass, at about 9am.
According to police, the pickup truck, registered in Bangkok, was driven by Chusak Charoenphon, who was accompanied by Suraphat Rueanrom. The pair were traveling from Graceland Khaolak Beach Resort to pick up goods in Phuket.
Due to the slippery road conditions caused by rain, the driver reportedly lost control while braking, causing the vehicle to crash into a barrier before crossing into the northbound lane and colliding with an oil tanker truck.
The tanker truck, registered in Surat Thani, was driven by Ms Manasaya Sinlaprommas.
Mr Chusak and Mr Suraphat suffered injuries and were taken to Thalang Hospital for medical treatment.
Police said they were continuing their investigations to confirm the circumstances leading to the crash. Alcohol and drug tests have been requested for the injured pickup truck occupants.