Patong police were called to the hotel, on Phra Mettha Rd, at about 6am.
Officers arrived and found no signs of a struggle in the room.
A nurse hired to look after the German man, 66, told police that the foreigner had suffered a urinary tract infection and had been bedridden for several months.
She reported that around 5:30am the German man had a fever and suffered bouts of dizziness. Despite her efforts to care for him, including wiping his body to alleviate his discomfort, his condition worsened and he ultimately passed away.
The man’s body was taken to Patong Hospital, where doctors have been asked to conduct a thorough post-mortem examination to confirm the cause of death.
German embassy representatives have been informed of the man’s passing.
* The Phuket News is withholding the man’s name until it has been confirmed his next of kin have been informed of his death.