Police and rescue workers were called to the scene, at a U-turn on Thepkrasattri Rd in Baan Lipon, Thalang, at about 6:45am.
According to Thalang Police, the crash involved several vehicles, including an orange Toyota Yaris sedan, a white Mitsubishi Pajero SUV and a Toyota Hilux pickup truck.
Pol Lt Chanita Bunyanuwat, Deputy Inspector (Investigation) at Thalang Police arrived at the scene along with a rescue unit from Srisoonthorn Municipality, who quickly rushed the injured to Thalang Hospital.
According to police, after reviewing CCTV footage, the white Mitsubishi Pajero registered in Bangkok was travelling northbound on Thepkrasattri Rd when it collided with a motorcycle.
The Pajero then crashed into the orange Phuket-registered Toyota Yaris, which was waiting to make a U-turn.
The Yaris then spun out and struck a Toyota Hilux pickup truck, registered in Krabi, which was waiting behind the Yaris to also make a U-turn.
CCTV footage confirmed the sequence of events, capturing the moment when the Mitsubishi Pajero collided with the Yaris before the Yaris hit the Hilux.
Police are continuing their investigation into the accident.