Chalong Police were called to the scene, opposite the Shell petrol station, at 7:30pm.
Officers arrived at the scene to find a blue Honda motorcycle registered in Kanchanaburi on the road
The driver, Detnarong Yodya, 30, of Kanchanaburi Province, and his passenger Natthakan Nikhomjit, 31, from Nakhon Sri Thammarat, had suffered injuries. Rescue workers from Rawai Municipality took them to Chalong Hospital.
The Chinese woman, identified as Xie Juxian, 58, from Sichuan, unconscious and unresponsive at the scene, was also taken to Chalong Hospital, where she was formally pronounced dead.
According to the police initial investigation, Ms Xie was crossing Wiset Rd to go to a fruit shop opposite the Shell petrol station when she was struck by the motorbike driven by Detnarong.
Police are continuing their investigation.