The new provisions aim to reduce road traffic accidents, and the Cabinet recently approved the need for motorists to have a health certificate and special training, the department said.
Yongyut Nakdaeng, Deputy Director-General of the department, said the Cabinet approved draft Ministerial Regulation to reduce accidents, enhance road safety and respond to current problems.
Under the draft regulation, those seeking to obtain or renew a licence will need to have their health certified, while those wishing to drive "big bikes" - motorbikes with engines 400cc or higher - will need to nudergo special training before being allowed on the road.
Of the 21,284,775 motorcycles registered in the country, 216,547 have engines of 400cc or larger, Mr Yongyut said.
The new rules will come into effect 120 days after they are published in the Government Gazette.