Kickoff will commence at 7pm at Surakul Stadium, where security is expected to be tighter than usual following recent attacks.
The match is both side's 18th of the 2016 season for the 22-fixture Division 2 South regional league.
Ranong United are currently in 3rd place with 28 points, while Phuket FC are in 6th with 23 points.
At the top of the table are Suraththani FC (35 points) and Nara United (32 points).
Only the top two sides of the region will earn a spot in the 12-club Champions League play off promotion to Division 1 at the end of the season.
Tickets are only B50 at the gates for adults, and free entry for students with ID and young children.
The Phuket News is a proud media partner with Phuket FC.