The driver of the other vehicle involved in the collision was also hospitalised with undisclosed injuries.
Thachadchai Police were notified of the accident at 11pm last night (August 13) and reported to the scene, on the two-lane road that runs parallel to the Phuket Airport runway in Mai Khao.
Rescue workers were dispatched, bringing special equipment to help free victims said to be trapped inside one of the cars.
The first vehicle was identified as a black Toyota saloon with Phang Nga license plates.
The front end of the vehicle was completely smashed up and there were several injured parties stuck inside.
Nearby there was a white Honda CRV with Phuket plates, which was also smashed in the front, but to a lesser degree.
Four family members rescued from the black Toyota were identified as Ms Kwankamol Panpuangkaeo, 35, the driver; Ms Wanna Panpuangkaeo, 57; Mr Phongpichet Panpuangkaeo, 58; and Ms Nattakan Panpuangkaeo, 21.
Of the four, Ms Nattakan was the only one who was reportedly still unresponsive by this morning, and has since been transferred to Vachira Phuket Hospital.
The fifth injured party was named as Mr Itthimon Thakoo, 23, the driver of the white CRV, and is recovering in Thalang Hospital, along with the other three injured-yet-responsive parties.
Pol Cap Thanom Thongpaen of Thachadchai Police said that leading up to the accident, the black Toyota is believed to have had just left the airport and was en route to Thepkrasattri Rd, while the white Honda is believed to have been coming from the opposite direction, and was on its way to the airport.
Pol Cap Thanom speculated further that one of the drivers had most likely crossed over into the wrong lane, causing the other oncoming to lose control, but he declined to appoint blame or speculate any further as the investigation is ongoing.