The crash took place at 8.30 am in front of the Bank of Ayudhya branch on the Pa Khlok Rd, about 700 metres from the Heroines Monument.
All three boys were rushed to Thalang Hospital where the driver of the bike, 15-year-old Chaiwat Chailiam, died of his injuries.
The other two, Pongsakorn Pannattee, 15, and Chatdanai Thammachot, 13, were stabilised and then moved to Vachira Phuket Hospital.
Ratchadaporn Ponkwamdee, 38, the driver of the pickup truck, told police that she was driving east and was making a turn into Niramit 5 Village, next to the bank. She paused before making the turn and then, she said, felt something smash into the back of her truck.