Police are claiming self-defence, as they say the escapees allegedly attacked the officers who were trying to take them into custody.
The alarm was raised at 3am, when guards at the centre noticed that bars on the windows of a second-floor cell had been cut. Police believe the escapees used hacksaw blades to cut the bars.
The escapees broke into two groups, with 15 heading down a canal which joins Phang Nga Bay and another six fleeing into the hills.
Officers in pursuit closed in on the six escapees in the hills, who they say attacked the officers. In the ensuing struggle, say police, one of the Rohingya escapees was fatally shot.
Police reported that three of the six in the hills were recaptured. No clarification was given on whether or not the remaining two of the six were taken into custody.
Police have yet to reveal any progress on apprehending the 15 escapees who fled down the canal.