The remote region is ringed with vast canyons and red mountains that, legends say, are stained with the blood of a demon killed by the founder of Tibetan Buddhism.
Yet the recently completed unpaved highway that connects Upper Mustang with China is also bringing unprecedented cultural change to a region that was closed off to foreign visitors until 1992.
In the medieval walled capital of Lo Manthang, young men have swapped Tibetan robes for blue jeans and local cafes broadcast live coverage of English Premier League matches to rapt viewers.
Nevertheless, while modern life holds considerable allure for many, the push to preserve traditional culture is no less important to the local Loba community. Buddhists who speak a variant of the Tibetan language, they have lived in Upper Mustang for centuries.
Nowhere is this more evident than in the ongoing effort to restore sacred murals and monuments, supported by foreign and Nepali non-profit organisations, including the Lo Gyalpo Jigme Foundation, which is headed by the former king of Upper Mustang.
Although the region’s rich heritage escaped the ravages of the Cultural Revolution that hit neighbouring China, its monuments fell prey to environmental damage.
Wind and rain eroded mud walls and caused wooden rooftop beams to decay, while smoke from ceremonial butter lamps darkened indoor frescos.
Over the last decade, restorers have been working hard to shore up structures, clean murals and retouch damaged paintings in line with Buddhist beliefs.
Buddhists believe it is better to pray to undamaged images of the Buddha, and see it as their duty to repair and retouch them when necessary.
The painstaking process involves grinding gemstones like lapis lazuli and malachite into a fine powder, which is then mixed with water and animal glue to create luminous pigments fit for gods.
After last year’s massive earthquake killed nearly 9,000 in Nepal and severely damaged monasteries in Lo Manthang, restorers now face an even bigger challenge.
Like many here, they too are locked in a race to preserve Upper Mustang’s unique cultural legacy for future generations.