The Islanders' French midfielder Geoffrey Doumeng opened the scoring in the 8th minute against the visiting East Coast team - known as the "Blue Marlins" - and Brazilian striker Dudu Purcino followed up with a goal in the 17th minute.
The visitors took a consolation goal early in the second half, but another goal from Dudu settled the score five minutes from full time - to the noisy delight of more than 4000 fans at Phuket's Surakul Stadium.
The home win for Phuket FC gives them a valuable three league points after the first two matches of the season - an away game against BBCU and a home game against Bangkok FC last weekend - both ended as draws.
Phuket next play on March 23 at Surakul in a Toyota League Cup game against PTT Rayong FC.
In other Yamaha League 1 games today, Khon Kaen lost 0-2 to Rayong United, Saraburi lost 1-2 to Singtharua, Krabi defeated Ayutthaya 3-0, and Navy drew nil-all with Big Bang Chula United (BBCU).
Phuket FC are now third in Division 1, click here to view the table.
For more photos and updates, visit the official Phuket FC Facebook page here.